18 Great Dane Mixes

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Last Updated on September 20, 2023

Quick Summary: Designer Dog Breeding is the practice of mixing 2 popular breeds of dogs. So, what happens when you mix Great Dane with the likes of Golden Retriever, Rottweiler, Siberian Husky, Poodle, American Bulldog, Saint Bernard, Pitbull, Doberman, and others? We can already tell that this is going to be exciting!

The Great Dane is known as a gentle giant whose love and devotion has made them the 16th most popular breed in the United States. The Great Dane is a popular breed to mix with other dogs in pursuit of the perfect giant breed. They are known for their beautiful features, gentle personality, and undeniable popularity.

This practice is called Designer Dog Breeding, which results in a mix of two purebred parents. This can also happen in nature, where purebred dogs mix with a Dane. In today’s article, we are going to look at 18 different Great Dane mixes that have been produced from mixing a Great Dane with another breed.

Many deserving mixed-breed dogs are in need of shelters all across the country. You can find the many adorable Great Dane hybrid dogs below in your local shelter if you are open to the idea.

Great Dane Blends

There are two ways to get Great Dane mixes: from the shelter or from buying one from a dog breeder. Many mixed-bred dogs are looking for their furever homes at your local shelters, so we encourage you to check them out.

These mixes may have different traits and appearances. Some mixes will be modeled after their Dane parent . The colors of the coats will vary from white to black or brindle, as well. You should plan ahead for a Great Dane-sized puppy to be adopted. An older Dane mix will give you a better idea of how big it will grow.

If you plan to shop, ensure you get your pup from a breeder where both parents are papered, to reduce the likelihood of health problems as your pup ages. The list below contains 18 of our favorite Great Dane mixes. There are many other Great Dane mixes out there, which we didn’t include in this article.

Great Retriever

Great Retriever

Breeds: Great Dane and Golden Retriever

The Great Retriever is just as amazing as their name implies! A more rare mix between the ever-popular Golden Retriever and the lovable Great Dane, this large breed dog is sure to win your heart.

This mix is likely to weigh between 60 to 190 pounds, but any potential owner should prepare to make room for the latter as mixed breed sizing can be somewhat of a guessing game.

This pup is the definition people-loving canine and just wants to be with those they love. The Great Retriever is not a good choice for being left alone, and the Great Dane is more susceptible to separation anxiety.

Because of their gentle and patient nature, this pup is great with families of any size. Families with young children should not leave their Great Retriever alone. Accidents can occur with large, playful breeds like this one.



Breeds: Great Dane and Doberman Pinscher

The Doberdane, a combination of a Great Dane and Doberman Pinscher is a powerful dog. This imposing canine can weigh up to 190 pounds and is considered a high-energy dog. We do not recommend this breed for inexperienced owners.

Doberdanes are very protective and need to be socialized early on in order to have a happy, healthy dog. You will be able to rely on your Doberdane as a guard dog.

A well-trained and socialized Doberdane can be affectionate, gentle, and loyal if they are properly trained. Although they can seem intimidating, this breed is capable of being a friendly and loving dog if provided with the right environment and leadership.

Due to their large size, Doberdanes should not be left alone with small animals or children. This is one of the more popular Doberman Pinscher mixes that you’ll see due to people that love Dobermans wanting to get a little extra size boost.



Breeds: Great Dane and Boxer

Meet the Boxane! A playful mix between a Boxer and a Great Dane. This puppy is likely to have a shorter coat.

It can either sport the straight-faced Boxer face or Dane’s facial features. Either way, this dog is very large and can weigh up to 150 pounds. Boxane is one the most active Great Dane mix, their Boxer parent being well-known for their playful and lively personality.

The Boxane is an athletic and agile dog that can be trained. However, it requires a strong leader to manage its size and strength. When training a Boxane, it’s important to note this breed can be both sensitive and stubborn so kind but firm training will give you the best results.

The Boxane, despite its intimidating stature, is a friendly and playful family dog that will keep you smiling.

Great Danoodle

Great Danoodle

Breeds: Great Dane and Poodle

The Great Danoodle is an uncommon mix between a Great Dane and a Standard-sized poodle. Rarely will you find a Great Dane and a Miniature Puppy mixed together. Due to this factor, and their Great Dane parentage, this pup will be quite large, generally reaching around 100 pounds. The Great Danoodle’s Poodle genes will ensure that there is very little shedding.

The Great Danoodle requires moderate exercise and is friendly with other dogs. This dog mix is reminiscent of a large Poodle, but with the facial and head features of a Great Dane.

The Great Danoodle’s parents are well-known for their obedience and willingness to please. They are able to be reserved with strangers and serve as a guard dog. But, once socialized properly, this puppy wants to be surrounded by their family , regardless of its age or size.

Great Hound

Great Hound

Breeds: Great Dane and Bloodhound

The Great Hound, a Bloodhound and Great Dane hybrid, is a giant breed dog which usually weighs between 100 and 200 pounds.

The friendly, pack-oriented pup loves being with their family. They may experience separation anxiety if they are left alone for a long time.

The Great Hound is stubborn and requires consistent training. This is necessary to train the Great Hound and give him the mental stimulation he needs. Also, a Bloodhound’s strong prey drive and hunting instincts mean that a Great Hound should not be left unattended.

These dogs are very loyal and make a wonderful addition to active families.

Great Pyredane

Great Pyredane

Breeds: Great Dane and Great Pyrenees

The Great Pyredane, a giant breed, is the result of a purebred Great Dane as well as a purebred Great Pyrenees. This breed is quite remarkable, as you may have guessed by their names.

This mix is independent, which can help to reduce separation anxiety that many Great Danes have. also, these dogs shed a lot all year, so make sure to vacuum often!

Because of the Great Pyredane’s large size and vocalizations, it is not recommended to keep them in an apartment. Likely inherited from their Great Pyrenees roots, who were bred as fierce defenders for flocks of sheep, this mix can exhibit overprotectiveness and should be properly socialized to ensure you can introduce a well adjusted and happy pup to strangers and other animals.

Great Danebull

Great Danebull

Breeds: Great Dane and PitBull

The Great Danebull is a hybrid American Pitbull Terrier and Great Dane. This large breed dog is extremely protective and powerful. We do not recommend the Great Danebull to a first dog owner due to its size and strength.

Although the Pitbull is known for their aggression, they can be a loving and affectionate breed if properly trained and socialized. The Great Danes are similar in their people-oriented nature, so this combination is sure to bring lots of love and devotion.

A Great Danebull will look a lot like a Pit Bull, but with a Great Dane’s face. Their short, dense and muscular coats tend to shed all year.

Although they may appear intimidating, these dogs are often gentle and calm. This trait is most likely inherited from their Great Dane heritage.

They are very eager to please, which makes them extremely trainable. However, they really just want to be with their families. This is a pretty common mix Pitbull mix, but not as popular as some others.

American Bull Dane

American Bull Dane

Breeds: Great Dane and American Bulldog

The American Bull Dane, an agile and powerful mix of an American Bulldog and Great Dane, is a fast and powerful combination. This mix is likely to be a large breed but can fall anywhere between a medium-sized 40-pound pup to a whopping 190-pound giant breed.

They are great guard dogs because they are brave and alert. However, they are also affectionate and playful.

A Bulldog parent could pass on the flat-faced traits to an American Bull Dane. This characteristic is known to cause health problems, including eye and respiratory issues. These risks should be known by any potential American Bull Dane owner.

This intelligent, dedicated breed is a great choice for people who are familiar with dominant breeds. They can set the right boundaries to allow this incredible mix to thrive.

Great Bernard a.k.a Saint Dane

Great Bernard

Breeds: Great Dane and Saint Bernard

A Great Bernard is also known as a Saint Dane, which is a cross between a Saint Bernard and a Great Dane. Expect a very large pup here, with two giant breed parents, this mix usually weighs between 120 and 190 pounds.

Their life expectancy is shorter than other dogs – they only live between 7 to 10 years. The Great Bernard is gentle with children, and makes a great companion pet.

Due to its massive stature, this puppy is not recommended for people who live in small apartments or are limited in space. You should expect them to have a large appetite, so you will need to spend more on their care and food than the average dog.

This giant-sized breed will be your best friend if you have the money and space. They will love you unconditionally and show you the affection, love, and gentleness they are known for.



Breeds: Great Dane and Mastiff

The Daniff is a large breed that has been created by combining a Great Dane with a Mastiff. It’s a popular mix, and in fact it’s one of the more popular mixes with a mastiff as the parent breed.

With two giant breed parents, this hybrid can reach impressive sizes, generally falling between 110 to 230 pounds! The Daniff is not recommended for everyone as it is one of the most large breeds on the list.

They require minimal maintenance and exercise, and shed very little. However, Daniffs are best suited to owners who have experience with large breeds.

The breeds are often compared, and when combined, the Daniff can be quite stubborn and will require patience and persistence to train. Another downside is this breed has a relatively short lifespan, usually living 6 to 10 years. Anyone considering adopting a Daniff should consider this.

The Daniff is a gentle giant and a wonderful companion for children.

Weiler Dane

Weiler Dane

Breeds: Great Dane and Rottweiler

A less common mix, the Great Dane and Rottweiler come together to make a powerful and impressive pup known as a Weiler Dane. This pup generally weighs between 80 and 190 pounds.

The Weiler Dane, despite their large size, is calm and low-energy. They can be housebroken if they get enough exercise. They can be stubborn and powerful so it is best to train them well.

The Weiler Dane is a cross between both parent breeds – the Rottweiler is known as a guard dog while the Dane is known for its gentleness and devotion. They can look like a taller Rottweiler which can make them intimidating.

Although the Weiler Dane is a protective breed, they are very friendly with children.

Great Dasenji

Great Dasenji

Breeds: Great Dane and Basenji

Meet The Great Dasenji. This unique mix of Great Dane and Basenji is a rare combination. This pup is one of the smaller mixes on our list, weighing between 60 to 85 pounds.

The Basenji is an independent and energetic breed, two strong characteristics that are likely to be present in this mix. This Great Dane mix will do better if they have regular stimulation and exercise. These dogs are intelligent and require mental stimulation as well as physical activity.

While they may be independent, the Great Dasenji retains the gentleness Great Danes are known for. They are a loving, affectionate breed who love to be with their family. However, they can be reserved and might take some time to become comfortable around other animals and humans. Positive reinforcement and socialization can make your Great Dasenji a more trusting dog.

Greater Swissdane

Greater Swissdane

Breeds: Great Dane and Greater Swiss Mountain Dog

The Greater Swissdane is a cross between a Greater Swiss Mountain Dog and a Great Dane. This large breed will likely weigh between 85 and 190 pounds.

Greater Swiss Mountain Dogs were created to be hardworking workers, and this trait will likely carry over to the mix. If you don’t provide enough outlets for your Greater Swissdane, you will end up with a bored, defiant, and sometimes even destructive dog.

This hybrid is more independent than other Great Dane mixes. They can show stubbornness and need consistent training from a strong leader. This intelligent breed is very trainable if given the right leadership.

The Greater Swissdane can be a joyful and affectionate breed if they are given the right structure and exercise.

Irish Dane

Irish Dane

Breeds: Great Dane and Irish Wolfhound

The Irish Dane, one of the largest dogs on this list, is a mix of Irish Wolfhound and Great Dane. This dog usually weighs between 110 and 200 pounds but can exceed that!

This breed should be accommodated in a large home, so make sure you have available space. The Irish Dane, like many other breeds we have highlighted, is a gentle giant who is affectionate and devoted to their family.

This mix will sometimes look a bit like the Scottish Deerhound, which is a breed that the Irish Wolfhound is often compared with.

They are gentle and get along with all animals. The Irish Dane is a great family pet and does well with children. They don’t bark and aren’t considered loud. They will fill your home with love and affection if you have enough space.

American Foxy Dane

American Foxy Dane

Breeds: Great Dane and American Foxhound

The American Foxy Dane is a hybrid of an American Foxhound and a Great Dane. This energetic breed needs plenty of exercise. They thrive in homes that can accommodate both their size and energy.

This breed usually falls between 80 and 120 pounds. They’re intelligent dogs and will respond well to positive reinforcement training.

This sweet mix is a great addition to any family! However, this pup is not a good choice for long-term alone time. Also, they can become withdrawn and unhappy if they don’t feel included in the family.

Before adopting an American Foxy Dane, you should think about your lifestyle and schedule. You need to make sure that you have the energy and time to devote to this loyal breed.

Weimar Dane

Weimar Dane

Breeds: Great Dane and Weimaraner

The Weimar Dane is a unique mix of Weimaraner and Great Dane. This dog will be large-sized to huge, and will require lots of exercises. Although the Weimaraner can be a very energetic dog, it will still need to be exercised regularly.

Due to their temperament and size, as well as the fact that they are quite vocal, we don’t recommend keeping a Weimar Dane in an apartment. If left unattended, this breed can become bored and exhibit destructive behavior.

This mix is a great companion and can be gentle and loving towards other animals and children if given the right attention.

Plush Danois

Plush Danois

Breeds: Great Dane and Anatolian Shepherd

A mix between an Anatolian Shepherd and a Great Dane is known as a Plush Danois. As both parents are giant breeds, the Plush Danois will also be of substantial size, generally weighing around 150 pounds.

The Plush Danois is not recommended to families with small children due to its size and protective nature. And although they can be territorial, socialization is a good idea.

The Plush Danois makes a great guard dog. However, they can become overprotective or even aggressive when they aren’t given the right training and socialization. Plush Danois thrives when a strong leader has had experience with giant breeds.

The Plush Danois can be a very loyal companion if it has the right structure.

Great Danesky

Great Danesky

Breeds: Great Dane and Siberian Husky

The Great Danesky is a majestic giant breed. A mix between a Siberian Husky and a Great Dane, this impressive pup can reach weights of up to 190lbs! This dog is gentle like the Great Dane and independent like the Husky. Although Danes can be lazy, Huskies were bred for running and we don’t recommend this breed to live in apartments.

The Great Dane’s coat is short, while the Husky has a thick double-layered coat. The Great Danesky can have one or both.

The Great Danesky mix is great for families with children. Both parent breeds are naturally good family dogs. They are gentle and protective of children. Due to their prey drive, they may not be suitable to live with small animals like cats and rabbits.

The Great Danesky is a great choice because of their balanced temperament. They have the Great Dane’s laid back personality and the Husky’s more boisterous nature.


Great Danes have been long been a favorite breed. This sweet, gentle breed brings warmth, love, and many other wonderful qualities to any mix. These are just some of our favorite Great Dane mixes, but you might be able to find many other Great Dane mix possibilities if you visit your local rescues and shelters before you go to breeders.

If you are considering purchasing a Great Dane, it is worth looking into a Great Dane mix. This can result in a healthier, more unique pup. You may be able to adopt a mixed-breed shelter dog and help it find its forever home. You could end up with a new best friend by looking into these great Great Dane mix dogs!

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